XWH - 05 - 2 - 0065 TITLE : Gynecologic Cancer Center for Racial Disparities PRINCIPAL INVESTIGATOR : LTC

The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation. Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 13. SUPPLEMENTARY NOTES 14. ABSTRACT There are significant health-related disparities in outcome among women in the U.S. with different types of gynecologic cancer. HYPOTHESIS: Poor outcome among minorities with gynecologic cancer exists because of biological differences in tumors related to race and ethnicity; cultural, social and psychological barriers to accessing care; less than optimal screening services and prevention strategies, and unequal provision of quality health care and tailored therapeutics. SPECIFIC AIMS: 1: An analysis of the genomic and proteomic expression of gynecologic cancers will be undertaken to determine if there are molecular differences that partially account for the poor outcome among minority patients with gynecologic cancer. This analysis will be expanded in future years to include larger under-served cohorts and comprehensive epidemiological data that will facilitate more detailed genetic and epigenetic analysis. 2: Epidemiological surveys will be used to identify demographic and behavioral differences that lead to poor outcome. We will preliminarily evaluate the use of psychosocial intervention on decreasing morbidity among minorities. 3: Development of Vaccine strategies and specific antibody reagents for the detection of unique targets that are differentially expressed between the African Americans and Caucasians with endometrial cancer. SIGNIFICANCE The incidence, severity, and overall burden of cancer in the U.S. vary by race, ethnicity or other demographic features. This project will focus on identifying the reasons underlying poor outcome among minority groups with gynecologic malignancy so that education, screening, prevention and treatment algorithms can be tailored to high risk populations in an effort to have the greatest impact on reducing morbidity and mortality among the underserved. INTRODUCTION: Narrative that briefly (one paragraph) describes …